Affiliated Faculty Information

I. Affiliated Faculty, Lerner Research Institute, Cleveland Clinic

Ashok Agarwal, Ph.D. Biological markers of oxidative stress; proteomic and bioinformatics in DNA damage, apoptosis and preserving fertility in patients with cancer; laboratory and clinical studies assessing the efficacy of certain antioxidants in improving male fertility
Suneel Apte, M.B.B.S, Ph.D.  Extracellular matrix; proteolysis; metalloproteinases; ADAMTS proteases; ADAMTS-like proteins; proteomics; morphogenesis; cardiovascular; musculoskeletal; birth defects; fetal-maternal medicine; eye disorders; neural tube; craniofacial development; smooth muscle; post-translational modification; inherited connective tissue disorders; osteoarthritis; primary cilium
Mark Aronica, M.D.  Mechanisms by which specific ECM proteins contribute to the onset of asthma
Kathleen Berkner, Ph.D.  Vitamin K; vitamin K-dependent protein carboxylation; hemostasis; anticoagulation; calcification; vitamin K-dependent clotting factors deficiency (VKCFD); pseudoxanthoma elasticum; warfarin resistance; gamma-glutamyl carboxylase; vitamin K oxidoreductase (VKOR)
Mark Brown, Ph.D.  Lipid metabolism; lipoprotein metabolism; atherosclerosis; obesity; diabetes; reverse cholesterol transport; triacylglycerol; nutrition
Tatiana Byzova, Ph.D.  Angiogenesis; endothelial cells; integrins; extracellular matrix; cell adhesion; tumor progression; vascular biology; signal transduction in endothelium and platelets; oxidative stress and vasculature; toll-like receptors in angiogenesis
Donna Driscoll, Ph.D.  RNA biology; mRNA translational control; nutritional regulation of gene expression; selenium
Serpil Erzurum, M.D.  Asthma; pulmonary vascular disease; hypoxia; metabolism
Stanley Hazen, M.D., Ph.D.  Inflammation; atherosclerosis; asthma; myeloperoxidase; cardiovascular diseases; HDL; peroxidases; airway remodeling; intestinal microbiota; gut flora; cardiometabolic disease
Christopher Hine, Ph.D.  Dietary restriction; aging; lifespan extension; stress resistance; exercise; hydrogen sulfide (H2S) production and metabolism; sulfur amino acid metabolism; endocrine signaling and longevity
Sadashiva Karnik, Ph.D.  GPCRs; angiotensin receptors; ARBs; biased signaling; cardiac hypertrophy; hypertension; heart failure; structure-function of GPCRs; transmembrane signaling; microRNA; gene expression; chromatin protein modifications; STAT3 and U-STAT3 signaling; RGS proteins
Xiaoxia Li, Ph.D.  Signal transduction in innate and adaptive immunity
Daniel Lindner, M.D., Ph.D.  Mechanisms of acquired drug resistance in renal cancer, development of more effective drugs to treat myelodysplastic syndrome and acute myelogenous leukemia
Thomas McIntyre, Ph.D.  Lipid mediators; inflammatory signaling; platelet biology; biochemistry; acute kidney injury
Richard Padgett, Ph.D.  Transcription; RNA processing; RNA splicing; splicing factors; relation to cancer and developmental diseases; gene structure and function; genomics; evolution of genomes; RNA biochemistry
Eugene Podrez, M.D., Ph.D.  Atherosclerosis; thrombosis; atherothrombosis; platelets; macrophage; scavenger receptors; LDL; HDL; cholesterol; phospholipids; oxidative stress; lipid peroxidation
Jun Qin, Ph.D.  Signal transduction; integrin; cell adhesion; cell migration; kinase; heart disease; cancer; structural biology; protein NMR; protein crystallography
Sujata Rao, Ph.D.  Eye; developmental biology; circadian clock; neurovascular development; thyroid hormone signaling; cone photoreceptors; vascular remodeling
Nima Sharifi, M.D.  Prostate cancer; androgens; metabolism; steroids; castration-resistant prostate cancer; androgen receptor; hormone therapy; medical oncology; dihydrotestosterone; enzymes; biochemistry
Robert Silverman, Ph.D.  Interferon; rnase l; antiviral innate immunity; oncolytic virotherapy, DNA methyltransferase inhibitor
Jonathan Smith, Ph.D.  Atherosclerosis; HDL metabolism; atrial fibrillation; genetics; genomics; eQTL; gene expression; reverse cholesterol transport; dysfunctional HDL; RNAseq; allelic expression imbalance; ABCA1; mouse models; zinc finger nuclease
George Stark, Ph.D.  Interferons; IL-6; NFkB; STAT3; EGFR; drug resistance; DNA repair; lung cancer; breast cancer; prostate cancer; glioblastoma; septic shock
Dennis Stuehr, Ph.D.  Inflammation; nitric oxide; heme transport; soluble guanylate cyclase; electron transfer
Wai Hong Wilson Tang, M.D.  Heart failure; cardiomyopathy; nitrative stress; metabolomics; cardio-renal syndrome
Bruce Trapp, Ph.D.  Multiple sclerosis; glia; oligodendrocytes; astrocytes; neuroprotection; myelin, autism
Bin Zhang, Ph.D.  Mechanism of intracellular trafficking in human disease development; protein secretion; endoplasmic reticulum stress; hemophilia; alpha-1-antitrypsin deficiency, cardiovascular diseases; cancer

II. Affiliated Faculty, Doctoral Clinical Laboratory Scientists

A. Robert J. Tomsich Pathology & Laboratory Medicine Institute, Cleveland Clinic
Edmund Z. Reineks, M.D., Ph.D., DABCC   Point of care testing; quality; lab directorship; special topics
Adam McShane, Ph.D., DABCC  Automated chemistry; cardiovascular disease; blood gases
Marvin Natowicz, M.D., Ph.D.   Biochemical genetics; metabolic diseases
Jessica Colon-Franco, Ph.D., DABCC  Endocrinology; special chemistry; leadership
Kamran Kadkhoda, Ph.D., DABMLI  Immunopathology; serology; allergy; cellular immunology
Grace Kroner, Ph.D.  Special chemistry; diabetes testing; laboratory test utilization; data analytics
B. Department of Pathology, Metrohealth Medical Center
C. Department of Pathology and Laboratory Medicine, Children's Hospital Medical Center of Akron
D. Quest Diagnostics Cleveland Hearthlab Center of Excellence
Deborah Sun, Ph.D.   Clinical laboratory operations and management

III. Affiliated Faculty Case Western Reserved University or MetroHealth/Case Western Reserve University

*Faculty with Primary position at MetroHealth Medical Center
Romani Andrea M.D., Ph.D.   Regulation of magnesium homeostasis and transport in mammalian cells
Ge Jin, Ph.D.   Mechanism of cancer cell-derived cytokines and/or metabolites; immune response and role of HIV-infection in development/progression of non-AIDS-defining cancers
*Jeffrey Schelling, M.D. (MetroHealth Medical Center/Case Western Reserve University)  Mechanisms of chronic kidney disease progression; in vitro molecular and cellular methods, animal models and human studies investigating glomerular and tubulointerstitial pathophysiology
*Bing-Cheng Wang, Ph.D.  (MetroHealth Medical Center/Case Western Reserve University)  Roles of Eph receptor tyrosine kinases in invasive growth and distal metastasis of cancer cells
Wen-Quan Zou, M.D., Ph.D.   Protein aggregation in the conformational diseases; pathologic prion proteins (PrPC and PrPSc) in prion diseases (PrD); neurotoxic amyloid β (Aβ) in Alzheimer disease (AD); Creutzfeldt-Jakob disease (CJD)

IV. Affiliated Faculty, Cleveland State University

Jamila Hirbawi, Ph.D. Manager, Freshman Chemistry Program, Department of Chemistry

V. Affiliated Faculty, NASA

James L. Smialek Ph.D. High-temperature oxidation; coatings