Chemistry
Contact Info
Mailing Address
Cleveland State University
Dept. of Chemistry
2121 Euclid Ave., CHM
Cleveland, OH 44115-2214
Campus Location
Science & Research Center (SR)
2351 Euclid Avenue, Rm. 397
Contact Us
Phone: 216.687.2451
Fax: 216.687.9298
m.r.jones@csuohio.edu
Chemistry Administration
Michael Kalafatis, Ph.D.
Expertise: Blood Coagulation and Thrombosis. Thrombosis is the primary cause of death worldwide and one of two major focuses of my research. My laboratory has a great deal of expertise in the biochemistry of coagulation.
Cancer and Apoptosis. Cancer is the second cause of death worldwide. The traditional way to treat cancer today is "cut, poison, and burn" which correlates to surgery, chemotherapy, and radiation respectively with the known devastating side effects. My laboratory is striving to establish a treatment for cancer that uses natural non-toxic substances.
Bin Su, Ph.D.
Expertise: Drug development, Cancer pharmacology, Endocrinology, African trypanosomiasis, Synthetic medicinal chemistry, Pharmacokinetic study.
Xue-Long Sun, Ph.D.
Expertise: Glycan-based antiviral and anti-inflammation drug development, immunomodulation, targeted drug delivery, nanomaterial, and biosensor applications.
Biomimetic synthesis of native anticoagulant biomolecules for compensation of their loss in the pathological site as an on-demand therapeutic strategy.
Profiling and modulating cell surface glycosylation pattern and cell function.
Eric W. Kipruto, Ph.D.
Jamila Hirbawi, Ph.D.
Michelle Jones
Christina Bachman-Kirchner
Full-Time Faculty
David Anderson, Ph.D.
Expertise: Novel HPLC-MS techniques to measure biological compounds in diagnosis/treatment and in understanding diseases, including proteins, peptides, gangliosides, and drugs. Developed gradient chromatofocusing technique in the separation of proteins by pH gradients on ion-exchange columns. Research in chromatographic theory involving fundamental parameters of mobile phase and compounds chromatographed predicting separation.
Mekki Bayachou, Ph.D.
Expertise: Functional biomaterials; antithrombotic surfaces; electron transfer; nitric oxide synthases; metalloproteins; metalloenzymes; cyt P450s; bio-electrochemistry; DNA sensors; DNA-protein interaction; small molecule metabolite sensors; nanotechnology.
Anthony Berdis, Ph.D.
Expertise: The Berdis lab is developing novel diagnostic and therapeutic agents against several types of cancers, including glioblastoma multiforme, breast, pancreatic, and various leukemias. His research involves developing artificial nucleosides that increase the efficacy of existing anti-cancer agents with the goal of effectively killing cancer cells while leaving normal cells unaffected.
Warren Boyd, Ph.D.
Expertise: Coordination chemistry of azodioxides, transition metal-catalyzed organic reactions, and metal-based anticancer agents.
Valentin Gogonea, Ph.D.
Expertise: Computational chemistry; enzyme reactivity; nitric oxide synthase; hydrogenase; cholesterol transport; deuterium exchange; quantum mechanical molecular mechanics; molecular dynamics; protein folding.
Michael Kalafatis, Ph.D.
Expertise: Blood Coagulation and Thrombosis. Thrombosis is the primary cause of death worldwide and one of two major focuses of my research. My laboratory has a great deal of expertise in the biochemistry of coagulation.
Cancer and Apoptosis. Cancer is the second cause of death worldwide. The traditional way to treat cancer today is "cut, poison, and burn" which correlates to surgery, chemotherapy, and radiation respectively with the known devastating side effects. My laboratory is striving to establish a treatment for cancer that uses natural non-toxic substances.
Yana Sandlers, Ph.D.
Expertise: Clinical chemistry; mass spectrometry; inborn errors of metabolism; metabolomics; induced stem cells derived cardiomyocytes (iPSCM); Barth syndrome; cardiomyopathy.
Bin Su, Ph.D.
Expertise: Protein secretion dysregulation in disease development, cargo receptors impact on bleeding disorders; vesicle formation, COPII, and human disease; engineering gene therapies.
Xue-Long Sun, Ph.D.
Expertise: Glycan-based antiviral and anti-inflammation drug development, immunomodulation, targeted drug delivery, nanomaterial, and biosensor applications.
Biomimetic synthesis of native anticoagulant biomolecules for compensation of their loss in the pathological site as an on-demand therapeutic strategy.
Profiling and modulating cell surface glycosylation pattern and cell function.
John Turner, Ph.D.
Expertise: Raman spectroscopy; fluorescence; infrared; IR; near infrared; NIR; visible; chemical imaging; multivariate analysis; chemometrics; mineral; biomineral; bone; teeth; biomaterials; implant materials; bioanalysis; spectral imaging; hyperspectral imaging; multispectral imaging; liquid crystal tunable filter; LCTF; acousto-optic tunable filter; AOTF; CCD; charge coupled device, spectroscopy; gemology; gemstone; miner- alogy; geology; Raman database; poly-llactide.
Aimin Zhou, Ph.D.
Expertise: Investigating the role of RNase L, a key enzyme in interferon action against viral infection and cell proliferation, in immune cell functions and the pathogenesis of inflammatory diseases such as diabetes, non-alcohol fatty liver disease, and acute kidney injury by using cell and animal models.
Adjunct Faculty
Mahesheema Ali, Ph.D.
Metro Health CWRU
Clinical chemistry, toxicology, POCT, rapid response labs.
Ashok Agarwal, Ph.D.
Cleveland Clinic
Biological markers of oxidative stress; proteomic and bioinformatics in DNA damage, apoptosis, and preserving fertility in patients with cancer; laboratory and clinical studies assessing the efficacy of certain antioxidants in improving male fertility.
Suneel Apte, M.B.B.S, Ph.D.
Cleveland Clinic
Extracellular matrix and matrix-degrading proteases in osteoarthritis and inflammatory arthritis, heart disease, aortic aneurysms; genetic disorders affecting heart, eyes, and limbs; biochemistry, cell biology, genetic and proteomic technologies.
Mark Aronica, M.D.
Cleveland Clinic
Components of the extracellular matrix in development and pathogenesis of asthma.
Kathleen Berkner, Ph.D.
Cleveland Clinic
Gamma-glutamyl carboxylation of vitamin K-dependent proteins in hemostasis, calcification, apoptosis, signal transduction and growth control; mouse models; proteomics; mutagenesis; cellular systems; biochemical studies.
Mark Brown, Ph.D.
Cleveland Clinic
Diet-microbe-host interactions in obesity, diabetes, cardiovascular disease, and cancer; diet and gene interactions non-alcoholic fatty liver disease (NAFLD) and alcohol-associated liver disease; nutrition and obesity mechanisms in gastrointestinal cancers.
Tatiana Byzova, Ph.D.
Cleveland Clinic
Neoangiogenesis; angiogenesis in wounds, cancer, ischemia; vascular dysfunction in aging and neurodegenerative diseases; cancer and inflammation-associated vascular pathologies and thrombosis; ex vivo and in vitro cell and molecular biology; advanced imaging; analysis of model and clinical samples.
Jan Claesen, Ph.D.
Cleveland Clinic
Defining signaling systems used as intra-and inter-bacterial communication in the gut and skin, and understanding the interactions between dietary components and the microbiota in the context of disease prevention. Identifying therapeutic targets that modulate the microbe–microbe and microbe–host cell interactions; microbiology; bacterial genetics; synthetic biology; small molecule biosynthesis; biochemistry.
Timothy Collier, Ph.D.
Cleveland HeartLab
Novel diagnostic and prognostic assays aimed at identifying risk of cardiovascular, metabolic, and endocrine disease.
Jessica Colon-Franco, Ph.D., DABCC
Cleveland Clinic
Endocrinology; special chemistry; leadership.
Serpil Erzurum, M.D.
Cleveland Clinic
Mechanisms of lung inflammation and remodeling that lead to lung disease; mechanisms of abnormalities in redox balance, signal transduction, accelerate arginine metabolism and impact nitric oxide (NO) production.
Paul Fox, Ph.D.
Cleveland Clinic
IFN-gamma signaling; mechanisms of blood vessel formation; ferroxidases in iron metabolism in inflammatory diseases and chronic renal failure.
Stanley Hazen, M.D., Ph.D.
Cleveland Clinic
Inflammation in cardiovascular diseases; myeloperoxidase in oxidant stress and cardiovascular diseases; HDL structure and function; intestinal microbiota in cardiometabolic disease; bench-to-bedside; basic/genetic, cellular, animal model, and human clinical investigations; variety of analytical methods including mass spectrometry.
Christopher Hine, Ph.D.
Cleveland Clinic
Hormonal and nutritional regulation of endogenous hydrogen sulfide (H2S) production and metabolism; H2S effects in biological pathways; regulation and function of H2S generating enzymes; diet, exercise, and pharmaceuticals harnessing endogenous H2S production for increased stress resistance, metabolic fitness, and lifespan.
Kamran Kadkhoda, Ph.D., DABMLI
Cleveland Clinic
Immunopathology; serology; allergy; cellular immunology.
Babal Kant Jha, Ph.D.
Cleveland Clinic
Functional basis of cancer promoting genetic and epigenetic defects in humans. Defects in cancer cells and develop therapeutic strategies to eliminate cancer. Translational research to protect and preserve normal cells while restricting/ eliminating cancer cell growth (Therapeutic targeting of TET dioxygenase deficiency, transient and reversible TET inhibition and expansion of stem and progenitor cells, heightened ER Stress Response as a targetable vulnerability in multiple myeloma).
Sadashiva Karnik, Ph.D.
Cleveland Clinic
Angiotensin II type 1 receptor (AT1R) structure, function, physiology, genetics and signaling; hypertension; cardiac hypertrophy; heart failure (HF); Approaches include transgenesis, molecular pharmacology, ligand design, membrane protein biochemistry, protein-protein interaction, signal transduction, gene regulation, micoRNA regulation, proteomics and post-translational modifications.
Grace Kroner, Ph.D., DABCC
Cleveland Clinic
Special chemistry; diabetes testing; laboratory test utilization; data analytics.
Daniel Lindner, M.D., Ph.D.
Cleveland Clinic
Mechanisms of acquired drug resistance in renal cancer, development of more effective drugs to treat myelodysplastic syndrome and acute myelogenous leukemia.
Thomas McIntyre, Ph.D.
Cleveland Clinic
Lipid mediators, in the innate immune or inflammatory system; phospholipid PAF activation of inflammatory cells in cardiovascular and renal systems; oxidized phospholipids in apoptosis, affecting platelets in thrombosis and vascular disease; acute kidney disease.
Adam McShane, Ph.D., DABCC
Cleveland Clinic
Automated chemistry; cardiovascular disease; blood gases
Marvin Natowicz, M.D., Ph.D.
Cleveland Clinic
Biochemical genetics; metabolic diseases
Ina Nemet, Ph.D.
Cleveland Clinic
Gut microbial metabolism and relationship between microbial metabolites and disease risks; conventionally raised and/or germ free host colonized with genetically engineered human commensals to demonstrate direct effects of particular enzyme/metabolite on the host; metabolomics (mass spectrometry) and clinical studies in tandem with mechanistic studies.
Richard Padgett, Ph.D.
Cleveland Clinic
Mechanisms of post-transcriptional RNA processing, pre-mRNA splicing; myelodysplastic syndrome or acute myeloid leukemia; mutations in a small RNA (RNU4ATAC) resulting in growth retardation, microcephaly and skeletal deformities; genetic signals promoting correct splicing of giant introns.
Eugene Podrez, M.D., Ph.D.
Cleveland Clinic
Inflammation and oxidative stress in atherosclerosis and thrombosis via lipid peroxidation and formation of bioactive lipids; induced platelet hyper-reactivity associated with dyslipoproteinemia; platelet scavenger receptors type B targeted for new therapies; mechanisms of lipid oxidation products impairing cholesterol efflux inducing intracellular cholesterol accumulation.
Jun Qin, Ph.D.
Cleveland Clinic
Protein-protein interactions in heart failure, diabetes, and cancer; integrins in cell adhesion, morphology, and motility; mechanisms of integrin-mediated protein interaction in signaling; structural biology techniques of NMR and crystallography.
Sujata Rao, Ph.D.
Cleveland Clinic
Circadian regulation of neuronal and vascular development in the eye; circadian regulation of endocrine function; role of circadian clock in inflammation in the retina.
Edmund Z. Reineks, M.D., Ph.D., DABCC
Cleveland Clinic
Point of care testing; quality; lab directorship; special topics.
Sarah Schumacher Bass, Ph.D.
Cleveland Clinic, (Cardiovascular and Metabolic Sciences)
Mechanisms that underlie the transition from adaptive to adverse remodeling, including changes in cardiac structure, function, metabolism, fibrosis, and arrhythmogenesis in various models of human disease. Cell culture, pharmacology, proteomics, histology, structure-based drug design, and transgenic models are techniques used.
Dahai Shao Ph.D.
Cleveland Clinic
Clinical/analytical chemistry, instrumental analysis, mass spectrometry, biochemistry, method development and validation
James L. Smialek Ph.D.
NASA
High-temperature oxidation; coatings.
Jonathan Smith, Ph.D.
Cleveland Clinic
Genes altering atherosclerosis susceptibility in a mouse model; HDL metabolism, reverse cholesterol transport; genetics and functional genomics of atrial fibrillation; cell/molecular biology; biochemistry; genetics/genomics.
George Stark, Ph.D.
Cleveland Clinic
Cell signaling mechanisms underlying innate immunity and cancer; insertional mutagenesis; responses to interferon; interferon synthesis in cancer; PD-L1 modulation of cellular response to IFN-1; novel therapies.
Dennis Stuehr, Ph.D.
Cleveland Clinic
Regulation of nitric oxide (NO) biosynthesis, impact of NO synthesis on cells and tissues; NO synthase chemistry, structure-function relationship, interaction with cellular proteins controlling activity; NO regulation of heme insertion into cellular proteins; protein nitration; protein nitration, its regulation, and its control of protein function.
Wai Hong Wilson Tang, M.D.
Cleveland Clinic
Mechanistic determinants of inflammation and cellular processes in heart failure and cardiomyopathy; genetic, proteomic, and metabolomic links to pathogenic pathways in human heart diseases and heart failure; metabolites and proteins measured by mass spectroscopy techniques or immunoassays; enzyme expression in explanted human hearts.
Bruce Trapp, Ph.D.
Cleveland Clinic
Cellular/molecular biology of myelination; pathogenesis of neurological disability in multiple sclerosis.
Oliver Wessely, Ph.D.
Cleveland Clinic
Kidney development and kidney diseases; molecular mechanisms governing the formation and maintenance of a functional kidney and pathophysiology in diseases; polycystic kidney disease; focal segmental glomerulosclerosis; renal cell carcinoma.
Bin Zhang, Ph.D.
Cleveland Clinic
Protein secretion dysregulation in disease development, cargo receptors impact on bleeding disorders; vesicle formation, COPII, and human disease; engineering gene therapies.
Contact Info
Mailing Address
Cleveland State University
Dept. of Chemistry
2121 Euclid Ave., CHM
Cleveland, OH 44115-2214
Campus Location
Science & Research Center (SR)
2351 Euclid Avenue, Rm. 397
Contact Us
Phone: 216.687.2451
Fax: 216.687.9298
m.r.jones@csuohio.edu